clinpgx-database
ClinPGx Database provides programmatic access to pharmacogenomics data for clinical decision support. Query gene-drug pairs, retrieve evidence-based CPIC guidelines, and access allele function information to inform genotype-guided dosing and precision medicine applications.
ClinPGx Database lets you query gene-drug interactions and CPIC guidelines for genotype-guided dosing decisions.
AI-generated summary based on this skill's SKILL.md
Install
synthetic-sciences/openscience/clinpgx-database · repository language: TypeScript
git clone https://github.com/synthetic-sciences/openscience
cp -r openscience/backend/cli/skills/databases/clinpgx-database ~/.claude/skills/clinpgx-databaseFrequently asked questions
AI-generated answers based on this skill's SKILL.md and metadata
What pharmacogenomics gene-drug interactions does ClinPGx Database cover?
ClinPGx Database provides programmatic access to pharmacogenomics data for clinical decision support, enabling queries of gene-drug pairs and retrieval of evidence-based CPIC guidelines. The database covers major drug-metabolizing enzymes like CYP2D6 and CYP2C19, as well as transporters and other pharmacogenes relevant to genotype-guided dosing and precision medicine applications.
How does ClinPGx Database help with CPIC guidelines and dosing recommendations?
ClinPGx Database retrieves CPIC guidelines for genotype-guided dosing decisions, helping clinicians make evidence-based medication adjustments based on patient genetic profiles. The database supports precision medicine workflows by connecting genetic variants to actionable dosing recommendations for drugs like warfarin, clopidogrel, and others requiring pharmacogenetic interpretation.
Can ClinPGx Database provide allele function and frequency data?
Yes, ClinPGx Database provides access to allele function, frequency, and phenotype data essential for pharmacogenomic interpretation. This information helps clinicians understand how specific genetic variants affect drug metabolism and response, supporting both research and clinical decision-making in precision medicine.
Does ClinPGx Database include FDA drug labels with pharmacogenomic information?
ClinPGx Database retrieves FDA and regulatory pharmacogenomic drug labeling information, helping clinicians identify genetic risk factors for adverse drug reactions and toxicity. The database integrates regulatory guidance with clinical annotations and literature evidence for gene-drug-disease relationships.
What genetic risk factors for adverse drug reactions does ClinPGx Database identify?
ClinPGx Database identifies genetic risk factors for adverse drug reactions and toxicity across multiple pharmacogenes. Examples include DPYD variants associated with fluoropyrimidine toxicity, HLA-B screening for abacavir hypersensitivity, and TPMT variants for azathioprine dose adjustment, supporting pre-emptive pharmacogenetic testing and medication therapy management.
Is ClinPGx Database suitable for pharmacogene panel analysis?
Yes, ClinPGx Database supports pharmacogene panel analysis and clinical pharmacogenetics implementation. It enables comprehensive analysis of drug metabolism genetic variants and pharmacokinetic pathway analysis, making it suitable for pre-emptive PGx testing and clinical decision support workflows in precision medicine.
SKILL.md
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ClinPGx Database
Overview
ClinPGx (Clinical Pharmacogenomics Database) is a comprehensive resource for clinical pharmacogenomics information, successor to PharmGKB. It consolidates data from PharmGKB, CPIC, and PharmCAT, providing curated information on how genetic variation affects medication response. Access gene-drug pairs, clinical guidelines, allele functions, and drug labels for precision medicine applications.
When to Use This Skill
This skill should be used when:
- Gene-drug interactions: Querying how genetic variants affect drug metabolism, efficacy, or toxicity
- CPIC guidelines: Accessing evidence-based clinical practice guidelines for pharmacogenetics
- Allele information: Retrieving allele function, frequency, and phenotype data
- Drug labels: Exploring FDA and other regulatory pharmacogenomic drug labeling
- **Pharmacogenomic
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backend/cli/skills/databases/clinpgx-database/SKILL.md
backend/cli/skills/databases/clinpgx-database/references/api_reference.md
backend/cli/skills/databases/clinpgx-database/scripts/query_clinpgx.py