{"enrichment":{"faq":[{"a":"ClinPGx Database provides programmatic access to pharmacogenomics data for clinical decision support, enabling queries of gene-drug pairs and retrieval of evidence-based CPIC guidelines. The database covers major drug-metabolizing enzymes like CYP2D6 and CYP2C19, as well as transporters and other pharmacogenes relevant to genotype-guided dosing and precision medicine applications.","q":"What pharmacogenomics gene-drug interactions does ClinPGx Database cover?"},{"a":"ClinPGx Database retrieves CPIC guidelines for genotype-guided dosing decisions, helping clinicians make evidence-based medication adjustments based on patient genetic profiles. The database supports precision medicine workflows by connecting genetic variants to actionable dosing recommendations for drugs like warfarin, clopidogrel, and others requiring pharmacogenetic interpretation.","q":"How does ClinPGx Database help with CPIC guidelines and dosing recommendations?"},{"a":"Yes, ClinPGx Database provides access to allele function, frequency, and phenotype data essential for pharmacogenomic interpretation. This information helps clinicians understand how specific genetic variants affect drug metabolism and response, supporting both research and clinical decision-making in precision medicine.","q":"Can ClinPGx Database provide allele function and frequency data?"},{"a":"ClinPGx Database retrieves FDA and regulatory pharmacogenomic drug labeling information, helping clinicians identify genetic risk factors for adverse drug reactions and toxicity. The database integrates regulatory guidance with clinical annotations and literature evidence for gene-drug-disease relationships.","q":"Does ClinPGx Database include FDA drug labels with pharmacogenomic information?"},{"a":"ClinPGx Database identifies genetic risk factors for adverse drug reactions and toxicity across multiple pharmacogenes. Examples include DPYD variants associated with fluoropyrimidine toxicity, HLA-B screening for abacavir hypersensitivity, and TPMT variants for azathioprine dose adjustment, supporting pre-emptive pharmacogenetic testing and medication therapy management.","q":"What genetic risk factors for adverse drug reactions does ClinPGx Database identify?"},{"a":"Yes, ClinPGx Database supports pharmacogene panel analysis and clinical pharmacogenetics implementation. It enables comprehensive analysis of drug metabolism genetic variants and pharmacokinetic pathway analysis, making it suitable for pre-emptive PGx testing and clinical decision support workflows in precision medicine.","q":"Is ClinPGx Database suitable for pharmacogene panel analysis?"}],"shadow_tags":["precision-dosing","genetic-biomarkers","drug-metabolism","clinical-guidelines","personalized-medicine","variant-interpretation","drug-safety","population-genetics","enzyme-activity","regulatory-labeling"],"summary_rewrite":"ClinPGx Database provides programmatic access to pharmacogenomics data for clinical decision support. Query gene-drug pairs, retrieve evidence-based CPIC guidelines, and access allele function information to inform genotype-guided dosing and precision medicine applications."},"files":[{"bytes":20974,"path":"backend/cli/skills/databases/clinpgx-database/SKILL.md","sha256":"56555fad2af3d0c64a0567e179d14f52b02822ff96b5121ca135161bdaa41ce8","url":"https://skillfed.io/files/synthetic-sciences/openscience/clinpgx-database/c6a6d809/SKILL.md"}],"id":"synthetic-sciences/openscience/clinpgx-database","links":{"html":"https://skillfed.io/synthetic-sciences/openscience/clinpgx-database","md":"https://skillfed.io/synthetic-sciences/openscience/clinpgx-database.md","repo":"https://github.com/synthetic-sciences/openscience"},"meta":{"agents_supported":[],"first_seen":"2026-07-28","forks":403,"language":"TypeScript","last_updated":"2026-07-27","license":"Apache-2.0","name":"clinpgx-database","publisher":"synthetic-sciences","stars":2896},"relations":{"similar":[{"id":"drshailesh88/integrated_content_OS/clinpgx-database"},{"id":"LeonChaoX/qinyan-academic-skills/clinpgx-database"},{"id":"foryourhealth111-pixel/Vibe-Skills/clinpgx-database"},{"id":"jaechang-hits/SciAgent-Skills/clinpgx-database"},{"id":"mims-harvard/ToolUniverse/tooluniverse-pharmacogenomics"},{"id":"mims-harvard/ToolUniverse/tooluniverse-drug-mechanism-research"},{"id":"mims-harvard/ToolUniverse/tooluniverse-clinical-data-integration"},{"id":"mims-harvard/ToolUniverse/tooluniverse-precision-medicine-stratification"},{"id":"mims-harvard/ToolUniverse/tooluniverse-clinical-guidelines"},{"id":"mims-harvard/ToolUniverse/tooluniverse-pharmacovigilance"}]},"slug":{"owner":"synthetic-sciences","repo":"openscience","skill":"clinpgx-database"},"version":"c6a6d809"}