tooluniverse-drug-repurposing
This skill systematically discovers drug repurposing opportunities by analyzing disease-target associations, drug mechanisms, and pathway overlap. It guides you through target-based, compound-based, and disease-driven workflows, then scores candidates by genetic evidence, safety profile, literature support, and drug properties to prioritize the most viable options.
tooluniverse-drug-repurposing identifies drug repurposing candidates by matching disease targets to existing approved drugs and evaluating feasibility.
AI-generated summary based on this skill's SKILL.md
Install
mims-harvard/ToolUniverse/tooluniverse-drug-repurposing · repository language: Python
git clone https://github.com/mims-harvard/ToolUniverse
cp -r ToolUniverse/skills/tooluniverse-drug-repurposing ~/.claude/skills/tooluniverse-drug-repurposingnpx skillfed install mims-harvard/ToolUniverse/tooluniverse-drug-repurposingFrequently asked questions
AI-generated answers based on this skill's SKILL.md and metadata
How does tooluniverse-drug-repurposing identify new uses for existing medications?
tooluniverse-drug-repurposing systematically discovers repurposing opportunities by analyzing disease-target associations, drug mechanisms, and pathway overlap. It guides you through target-based, compound-based, and disease-driven workflows to match approved drugs with new disease indications based on shared molecular mechanisms.
Can tooluniverse-drug-repurposing find drugs for rare diseases?
Yes. tooluniverse-drug-repurposing specializes in identifying approved drugs for orphan and rare disease indications by building drug-target-disease networks. It evaluates genetic evidence, safety profiles, and literature support to surface viable candidates that may already be available in the clinic.
What does tooluniverse-drug-repurposing evaluate when assessing drug repositioning candidates?
tooluniverse-drug-repurposing evaluates drug-target-disease network reasoning with mechanism rationale, clinical trial precedent, and regulatory feasibility. It prioritizes candidates by evidence strength, safety profile, bioactivity, target affinity, and drug properties to identify the most promising repurposing opportunities.
How does computational drug repurposing analysis work in this skill?
tooluniverse-drug-repurposing performs computational analysis through disease target drug matching and drug-target network analysis. It assesses off-target drug activity, pathway-based mechanisms, and compound-based indication discovery to generate and rank drug repurposing hypotheses grounded in molecular evidence.
What is the basis for tooluniverse-drug-repurposing's candidate prioritization?
tooluniverse-drug-repurposing prioritizes repurposing candidates using a multi-factor scoring approach: genetic evidence strength, clinical trial precedent, drug safety profile evaluation, bioactivity and target affinity data, and literature support. This ensures the most viable and evidence-backed options rise to the top.
Is tooluniverse-drug-repurposing suitable for FDA-approved drug new indication discovery?
Yes. tooluniverse-drug-repurposing assesses clinical trial precedent and regulatory feasibility for repurposing, making it well-suited for identifying FDA-approved drugs for new indications. It evaluates drug repositioning feasibility and mechanism-disease relevance to guide regulatory-aware candidate selection.
SKILL.md
rendered from the published skill — quoted content, verbatim
Drug Repurposing with ToolUniverse
Systematically identify and evaluate drug repurposing candidates using multiple computational strategies.
IMPORTANT: Always use English terms in tool calls. Respond in the user's language.
Reasoning Before Searching
Start by asking: WHY might this drug work for a new disease? Three strategies:
- (a) Same target: The drug's primary target is also involved in the new disease. This is the strongest hypothesis — use OpenTargets to check if the target has genetic evidence in both diseases before any other search.
- (b) Off-target activity: The drug has secondary targets or off-target effects that are relevant to the new disease. Check ChEMBL
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skills/tooluniverse-drug-repurposing/EXAMPLES.md
skills/tooluniverse-drug-repurposing/PROCEDURES.md
skills/tooluniverse-drug-repurposing/REFERENCE.md
skills/tooluniverse-drug-repurposing/REPORT_TEMPLATE.md
skills/tooluniverse-drug-repurposing/SKILL.md
skills/tooluniverse-drug-repurposing/strategies_and_patterns.md