mims-harvard

This skill audits ToolUniverse documentation for technical errors, outdated information, and unnecessary duplication. It runs five phases—static method scanning, live code…

ToolUniverse setup guides you through installing and configuring the platform across three access modes: chat-based MCP for AI assistants, command-line interface with nine…

Query evidence-graded clinical guidelines from 12+ authoritative organizations including NICE, WHO, and specialty societies. Retrieve treatment recommendations, dosing protocols,…

This skill automates ToolUniverse setup for Claude Science by creating a conda environment, installing the pip package, and bundling the workflow library into a native skill. It…

This skill systematically discovers drug repurposing opportunities by analyzing disease-target associations, drug mechanisms, and pathway overlap. It guides you through…

Access histone ChIP-seq data, chromatin accessibility maps, and regulatory element annotations from ENCODE and Roadmap Epigenomics to investigate chromatin state by tissue,…

This skill maps transcription factor regulation by combining binding motif analysis, chromatin immunoprecipitation data, and expression quantitative trait loci to answer which TFs…

This skill applies Bayesian fine-mapping methods to pinpoint causal variants within GWAS-associated regions, moving beyond the lead SNP to compute posterior probabilities for each…

This skill enables systematic comparison of genome-wide association studies for any trait, aggregating effect sizes across studies and evaluating replication success. It…

Identify genes associated with diseases and traits by querying GWAS Catalog and Open Targets Genetics data. This skill ranks candidate genes using locus-to-gene scores that…

Combine quantitative results from two or more studies into a pooled estimate and confidence interval, with built-in heterogeneity assessment (I², Q, τ²). The skill converts raw…

Access CPIC guidelines, dosing recommendations, and metabolizer phenotype classifications for pharmacogenomic gene-drug interactions. Query allele functional status, variant…

Tooluniverse Phewas inverts the GWAS paradigm by fixing a variant or gene and scanning the entire phenome across four ancestry-matched biobanks plus exome-wide gene-burden data.…

Analyze genetic variation at the population level using integrated access to gnomAD, 1000 Genomes, GWAS Catalog, and clinical variant databases. Compute Hardy-Weinberg…

Query the 1000 Genomes Project (IGSR) to find populations and samples stratified by superpopulation codes, explore data collections, and retrieve population-specific allele…

This skill systematically maps gene regulation by integrating transcription factor motifs (JASPAR), experimental ChIP-seq and chromatin data (ENCODE), regulatory variant scoring…

This skill systematically evaluates non-coding variants through GWAS associations, tissue-specific eQTL effects, and regulatory context. It integrates ENCODE chromatin marks,…

ToolUniverse SDK provides a Python interface to compose and execute scientific research pipelines across protein analysis, drug discovery, genomics, and disease databases. Call…

This skill assembles comprehensive target intelligence by systematically exploring genetic associations, tissue expression patterns, pathway involvement, protein interactions,…

This skill combines multiple authoritative databases to deliver protein-level variant annotation, mapping structural domains, conservation patterns, clinical classifications, and…

This skill maps the causal chain from a genetic variant to its disease mechanism by querying regulatory context, target genes, molecular pathways, and phenotypic consequences…