Skills by mims-harvard
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tooluniverse-clinical-guidelines
Apache-2.0· ★ 1,595 · updated 2026-07-27 — Query evidence-graded clinical guidelines from 12+ authoritative organizations including NICE, WHO, and specialty societies. Retrieve treatment recommendations, dosing protocols,…
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tooluniverse-epigenomics-chromatin
Apache-2.0· ★ 1,595 · updated 2026-07-27 — Access histone ChIP-seq data, chromatin accessibility maps, and regulatory element annotations from ENCODE and Roadmap Epigenomics to investigate chromatin state by tissue,…
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tooluniverse-gene-regulatory-networks
Apache-2.0· ★ 1,595 · updated 2026-07-27 — This skill maps transcription factor regulation by combining binding motif analysis, chromatin immunoprecipitation data, and expression quantitative trait loci to answer which TFs…
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tooluniverse-gwas-finemapping
Apache-2.0· ★ 1,595 · updated 2026-07-27 — This skill applies Bayesian fine-mapping methods to pinpoint causal variants within GWAS-associated regions, moving beyond the lead SNP to compute posterior probabilities for each…
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tooluniverse-gwas-study-explorer
Apache-2.0· ★ 1,595 · updated 2026-07-27 — This skill enables systematic comparison of genome-wide association studies for any trait, aggregating effect sizes across studies and evaluating replication success. It…
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tooluniverse-gwas-trait-to-gene
Apache-2.0· ★ 1,595 · updated 2026-07-27 — Identify genes associated with diseases and traits by querying GWAS Catalog and Open Targets Genetics data. This skill ranks candidate genes using locus-to-gene scores that…
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tooluniverse-meta-analysis
Apache-2.0· ★ 1,595 · updated 2026-07-27 — Combine quantitative results from two or more studies into a pooled estimate and confidence interval, with built-in heterogeneity assessment (I², Q, τ²). The skill converts raw…
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tooluniverse-pharmacogenomics
Apache-2.0· ★ 1,595 · updated 2026-07-27 — Access CPIC guidelines, dosing recommendations, and metabolizer phenotype classifications for pharmacogenomic gene-drug interactions. Query allele functional status, variant…
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Tooluniverse Phewas
Apache-2.0· ★ 1,595 · updated 2026-07-27 — Tooluniverse Phewas inverts the GWAS paradigm by fixing a variant or gene and scanning the entire phenome across four ancestry-matched biobanks plus exome-wide gene-burden data.…
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tooluniverse-population-genetics
Apache-2.0· ★ 1,595 · updated 2026-07-27 — Analyze genetic variation at the population level using integrated access to gnomAD, 1000 Genomes, GWAS Catalog, and clinical variant databases. Compute Hardy-Weinberg…
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tooluniverse-population-genetics-1000genomes
Apache-2.0· ★ 1,595 · updated 2026-07-27 — Query the 1000 Genomes Project (IGSR) to find populations and samples stratified by superpopulation codes, explore data collections, and retrieve population-specific allele…
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tooluniverse-regulatory-genomics
Apache-2.0· ★ 1,595 · updated 2026-07-27 — This skill systematically maps gene regulation by integrating transcription factor motifs (JASPAR), experimental ChIP-seq and chromatin data (ENCODE), regulatory variant scoring…
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tooluniverse-regulatory-variant-analysis
Apache-2.0· ★ 1,595 · updated 2026-07-27 — This skill systematically evaluates non-coding variants through GWAS associations, tissue-specific eQTL effects, and regulatory context. It integrates ENCODE chromatin marks,…
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tooluniverse-variant-functional-annotation
Apache-2.0· ★ 1,595 · updated 2026-07-27 — This skill combines multiple authoritative databases to deliver protein-level variant annotation, mapping structural domains, conservation patterns, clinical classifications, and…
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tooluniverse-variant-to-mechanism
Apache-2.0· ★ 1,595 · updated 2026-07-27 — This skill maps the causal chain from a genetic variant to its disease mechanism by querying regulatory context, target genes, molecular pathways, and phenotypic consequences…