{"enrichment":{"faq":[{"a":"gwas-database provides direct access to the NHGRI-EBI GWAS Catalog, where you can search for SNP-trait associations by entering your disease or trait of interest. Query for type 2 diabetes to retrieve all associated genetic variants with their p-values, effect sizes, and supporting study metadata for epidemiological analysis.","q":"How do I find SNP associations with type 2 diabetes in gwas-database?"},{"a":"gwas-database lets you search by rs ID to identify all trait associations for that specific variant. Results include p-values, odds ratios or beta coefficients, associated phenotypes, sample sizes, and links to original GWAS publications\u2014essential data for understanding a variant's role across multiple diseases.","q":"What can I retrieve using an rs ID variant lookup in gwas-database?"},{"a":"Yes. gwas-database identifies genetic variants suitable for polygenic risk score construction by retrieving genome-wide significant hits with effect sizes and p-values. Filter results by ancestry, study population, and significance thresholds to select variants that meet your score's statistical criteria.","q":"Can gwas-database help me construct a polygenic risk score?"},{"a":"gwas-database supports gene-name queries to find all variants within or near your target gene. Results map SNPs to genomic regions and associated traits, allowing you to explore how genetic variation at that locus influences multiple phenotypes across published GWAS studies.","q":"How do I search the GWAS catalog by gene name using gwas-database?"},{"a":"gwas-database provides access to ancestry-specific and population-level genetic associations from the GWAS Catalog. You can filter results by ancestry group to examine how variant-trait associations vary across populations, supporting more inclusive and representative genetic epidemiology research.","q":"Does gwas-database include ancestry-specific genetic associations?"},{"a":"gwas-database returns comprehensive GWAS metadata including p-values, effect sizes, sample sizes, study design, publication details, and chromosomal coordinates. Access to these summary statistics supports validation studies, meta-analyses, and functional annotation of genome-wide significant variants.","q":"What metadata and summary statistics does gwas-database provide?"}],"shadow_tags":["snp-discovery","phenotype-mapping","genomic-epidemiology","variant-annotation","risk-prediction","population-genetics","association-statistics","biomedical-research","allele-frequency","disease-genetics"],"summary_rewrite":"Access the NHGRI-EBI GWAS Catalog to find genetic variant associations with diseases and traits. Search by rs ID, phenotype, gene, or genomic region to retrieve p-values, effect sizes, and study metadata for epidemiological research and risk score development."},"files":[{"bytes":20111,"path":"backend/cli/skills/databases/gwas-database/SKILL.md","sha256":"4f45fdc43ad70589fc460034655a3625aa7d14b8b726ec1db88ea5740630844a","url":"https://skillfed.io/files/synthetic-sciences/openscience/gwas-database/0355e549/SKILL.md"}],"id":"synthetic-sciences/openscience/gwas-database","links":{"html":"https://skillfed.io/synthetic-sciences/openscience/gwas-database","md":"https://skillfed.io/synthetic-sciences/openscience/gwas-database.md","repo":"https://github.com/synthetic-sciences/openscience"},"meta":{"agents_supported":[],"first_seen":"2026-07-28","forks":403,"language":"TypeScript","last_updated":"2026-07-27","license":"Apache-2.0","name":"gwas-database","publisher":"synthetic-sciences","stars":2896},"relations":{"similar":[{"id":"LeonChaoX/qinyan-academic-skills/gwas-database"},{"id":"drshailesh88/integrated_content_OS/gwas-database"},{"id":"jaechang-hits/SciAgent-Skills/gwas-database"},{"id":"mims-harvard/ToolUniverse/tooluniverse-gwas-trait-to-gene"},{"id":"mims-harvard/ToolUniverse/tooluniverse-regulatory-variant-analysis"},{"id":"mims-harvard/ToolUniverse/tooluniverse-variant-to-mechanism"},{"id":"mims-harvard/ToolUniverse/tooluniverse-polygenic-risk-score"},{"id":"mims-harvard/ToolUniverse/tooluniverse-population-genetics-1000genomes"},{"id":"mims-harvard/ToolUniverse/tooluniverse-gwas-study-explorer"},{"id":"mims-harvard/ToolUniverse/tooluniverse-gwas-snp-interpretation"}]},"slug":{"owner":"synthetic-sciences","repo":"openscience","skill":"gwas-database"},"version":"0355e549"}