{"enrichment":{"faq":[{"a":"tooluniverse-population-genetics-1000genomes lets you query the 1000 Genomes Project (IGSR) to find and filter samples by superpopulation codes (AFR, AMR, EAS, EUR, SAS) and individual population identifiers like YRI, GBR, CHB, and CEU. You can retrieve sample metadata and stratify cohorts by continental ancestry for downstream analysis.","q":"How do I search 1000 Genomes samples by ancestry?"},{"a":"tooluniverse-population-genetics-1000genomes provides population-specific variant frequencies across all five superpopulations: AFR (African), AMR (Americas), EAS (East Asian), EUR (European), and SAS (South Asian). You can look up allele frequencies by population code and compare frequency distributions across continental groups for fine-mapping and association studies.","q":"What population-specific allele frequencies can I access?"},{"a":"Yes. tooluniverse-population-genetics-1000genomes integrates population metadata with GWAS tools to enable ancestry-dependent genetic association analysis. You can analyze population stratification, identify population-specific effects, and account for continental ancestry in your statistical models to reduce confounding.","q":"Can I perform ancestry-aware GWAS analysis with this skill?"},{"a":"tooluniverse-population-genetics-1000genomes retrieves linkage disequilibrium (LD) structure and allele frequency patterns stratified by population. This allows you to compare LD blocks across AFR, AMR, EAS, EUR, and SAS groups for fine-mapping, identify population-specific associations, and assess genetic drift and population differentiation.","q":"How does tooluniverse-population-genetics-1000genomes compare LD patterns across populations?"},{"a":"tooluniverse-population-genetics-1000genomes provides access to 1000 Genomes Project data collections, sample metadata, and IGSR population information. You can explore available cohorts, retrieve superpopulation codes, and access population-specific variant data to design cohort-specific analyses tailored to your research question.","q":"What 1000 Genomes data collections and metadata are available?"}],"shadow_tags":["ancestry-stratified","superpopulation-codes","allele-frequency-lookup","genetic-diversity","population-differentiation","ld-structure-ancestry","admixed-populations","cohort-composition","fine-mapping-resolution"],"summary_rewrite":"Query the 1000 Genomes Project (IGSR) to find populations and samples stratified by superpopulation codes, explore data collections, and retrieve population-specific allele frequencies. Combine population metadata with GWAS tools to analyze ancestry-dependent genetic associations and identify population-specific effects."},"files":[{"bytes":10796,"path":"skills/tooluniverse-population-genetics-1000genomes/SKILL.md","sha256":"b6dd0d2e40e26f08e26e5e571f17463a082f8525fea8e59eec2e60d518e4c28b","url":"https://skillfed.io/files/mims-harvard/ToolUniverse/tooluniverse-population-genetics-1000genomes/69f4022f/SKILL.md"}],"id":"mims-harvard/ToolUniverse/tooluniverse-population-genetics-1000genomes","links":{"html":"https://skillfed.io/mims-harvard/ToolUniverse/tooluniverse-population-genetics-1000genomes","md":"https://skillfed.io/mims-harvard/ToolUniverse/tooluniverse-population-genetics-1000genomes.md","repo":"https://github.com/mims-harvard/ToolUniverse"},"meta":{"agents_supported":[],"first_seen":"2026-07-28","forks":242,"language":"Python","last_updated":"2026-07-27","license":"Apache-2.0","name":"tooluniverse-population-genetics-1000genomes","publisher":"mims-harvard","stars":1595},"relations":{"similar":[{"id":"jaechang-hits/SciAgent-Skills/gnomad-database"},{"id":"K-Dense-AI/scientific-agent-skills/onekgpd"},{"id":"LeonChaoX/qinyan-academic-skills/gnomad-database"},{"id":"beita6969/ScienceClaw/gnomad-database"},{"id":"Delphine-L/claude_global/gnomad"},{"id":"mims-harvard/ToolUniverse/tooluniverse-phewas"},{"id":"mims-harvard/ToolUniverse/tooluniverse-population-genetics"},{"id":"mims-harvard/ToolUniverse/tooluniverse-gwas-study-explorer"},{"id":"mims-harvard/ToolUniverse/tooluniverse-polygenic-risk-score"},{"id":"mims-harvard/ToolUniverse/tooluniverse-gwas-snp-interpretation"}]},"slug":{"owner":"mims-harvard","repo":"ToolUniverse","skill":"tooluniverse-population-genetics-1000genomes"},"version":"69f4022f"}