{"enrichment":{"faq":[{"a":"tooluniverse-pharmacogenomics retrieves CPIC dosing guidelines and metabolizer phenotype recommendations for gene-drug pairs like CYP2D6 and codeine. The skill interprets star alleles to predict metabolizer status from patient genotype, enabling clinicians to identify poor metabolizers who require dose adjustments or alternative medications.","q":"How does tooluniverse-pharmacogenomics help with CYP2D6 poor metabolizer codeine dosing?"},{"a":"tooluniverse-pharmacogenomics accesses CPIC guidelines, dosing recommendations, and metabolizer phenotype classifications for pharmacogenomic gene-drug interactions. It retrieves evidence-graded clinical guidance to support actionable PGx recommendations tailored to individual patient genotypes.","q":"What CPIC guidelines and recommendations does this skill provide?"},{"a":"Yes. tooluniverse-pharmacogenomics interprets star alleles and predicts metabolizer status from patient genotype data. It classifies phenotypes (poor, intermediate, normal, ultra-rapid metabolizers) and generates activity scores to inform dosing and drug selection decisions.","q":"Can tooluniverse-pharmacogenomics interpret star alleles and predict metabolizer status?"},{"a":"tooluniverse-pharmacogenomics retrieves FDA pharmacogenomic biomarker labeling and regulatory PGx status for drugs. It identifies which medications carry FDA-recognized genetic biomarker requirements or recommendations to ensure compliance with current labeling standards.","q":"How does tooluniverse-pharmacogenomics find FDA biomarker labeling?"},{"a":"tooluniverse-pharmacogenomics annotates genetic variants with PharmGKB clinical significance and evidence levels. It grades variant-drug response associations and identifies clinically actionable PGx findings to support evidence-based therapeutic recommendations.","q":"What variant annotations and evidence levels does this skill provide?"},{"a":"Yes. tooluniverse-pharmacogenomics generates evidence-graded clinical PGx reports with actionable recommendations. Reports integrate CPIC guidelines, metabolizer phenotypes, FDA biomarker status, and variant annotations into comprehensive, clinically-actionable summaries for patient care.","q":"Can tooluniverse-pharmacogenomics generate a clinical PGx report?"}],"shadow_tags":["precision-medicine","clinical-pharmacology","genomic-dosing","metabolizer-phenotypes","drug-metabolism-genes","variant-interpretation","evidence-grading","therapeutic-guidance","biomarker-labeling","allele-annotation"],"summary_rewrite":"Access CPIC guidelines, dosing recommendations, and metabolizer phenotype classifications for pharmacogenomic gene-drug interactions. Query allele functional status, variant annotations, and FDA biomarker labeling to support clinically-actionable PGx reports."},"files":[{"bytes":20545,"path":"skills/tooluniverse-pharmacogenomics/SKILL.md","sha256":"fa25cae06e0dd12223bf05885a481c3bdab00fe538a122f92b9d3b5ae82eb094","url":"https://skillfed.io/files/mims-harvard/ToolUniverse/tooluniverse-pharmacogenomics/707c9be5/SKILL.md"}],"id":"mims-harvard/ToolUniverse/tooluniverse-pharmacogenomics","links":{"html":"https://skillfed.io/mims-harvard/ToolUniverse/tooluniverse-pharmacogenomics","md":"https://skillfed.io/mims-harvard/ToolUniverse/tooluniverse-pharmacogenomics.md","repo":"https://github.com/mims-harvard/ToolUniverse"},"meta":{"agents_supported":[],"first_seen":"2026-07-28","forks":242,"language":"Python","last_updated":"2026-07-27","license":"Apache-2.0","name":"tooluniverse-pharmacogenomics","publisher":"mims-harvard","stars":1595},"relations":{"similar":[{"id":"synthetic-sciences/openscience/clinpgx-database"},{"id":"LeonChaoX/qinyan-academic-skills/clinpgx-database"},{"id":"foryourhealth111-pixel/Vibe-Skills/clinpgx-database"},{"id":"drshailesh88/integrated_content_OS/clinpgx-database"},{"id":"jaechang-hits/SciAgent-Skills/clinpgx-database"},{"id":"mims-harvard/ToolUniverse/tooluniverse-clinical-guidelines"},{"id":"mims-harvard/ToolUniverse/tooluniverse-drug-mechanism-research"},{"id":"mims-harvard/ToolUniverse/tooluniverse-precision-medicine-stratification"},{"id":"mims-harvard/ToolUniverse/tooluniverse-clinical-data-integration"},{"id":"mims-harvard/ToolUniverse/tooluniverse-pharmacovigilance"}]},"slug":{"owner":"mims-harvard","repo":"ToolUniverse","skill":"tooluniverse-pharmacogenomics"},"version":"707c9be5"}