{"enrichment":{"faq":[{"a":"gtex-database provides access to the GTEx portal's REST API, enabling you to explore how genetic variants regulate gene expression across 54 human tissues. The skill helps you find eQTL associations for GWAS variants, retrieve tissue-specific expression levels in TPM units, identify splicing QTLs, and uncover regulatory mechanisms underlying non-coding variants. It's licensed under MIT.","q":"What is gtex-database and what can it help me find?"},{"a":"gtex-database lets you query eQTL variants to discover gene regulation patterns. You can look up specific variants to find which genes they regulate, retrieve eGenes by tissue type, and map GWAS loci to their target genes through eQTL associations. The skill supports variant-to-gene mapping across all 54 tissues in the GTEx dataset.","q":"How do I query eQTL variants for gene regulation using gtex-database?"},{"a":"Yes, gtex-database retrieves tissue-specific gene expression levels across GTEx's 54 human tissues. You can compare gene expression patterns across multiple tissues for annotation purposes, access TPM values for your genes of interest, and perform multi-tissue expression comparisons to understand tissue-dependent regulation.","q":"Can gtex-database help me find tissue-specific expression levels?"},{"a":"gtex-database helps you discover splicing QTLs (sQTLs)\u2014genetic variants that affect gene isoform usage rather than overall expression levels. The skill identifies tissue-specific sQTL effects, allowing you to understand how variants influence alternative splicing patterns across different tissues and uncover regulatory mechanisms for non-coding variants.","q":"What are splicing QTLs and how does gtex-database help discover them?"},{"a":"gtex-database enables GWAS variant interpretation by finding eQTL associations that explain regulatory effects of your variants. You can map GWAS loci to regulated genes, perform multi-tissue eQTL colocalization analysis, and identify which tissues show the strongest regulatory effects for your variants of interest.","q":"How can gtex-database support GWAS variant interpretation?"},{"a":"gtex-database accesses the GTEx portal's comprehensive gene expression atlas covering 54 human tissues. It provides expression quantitative trait loci (eQTL) data, splicing QTL information, and tissue-specific expression measurements. The skill integrates with the GTEx REST API for programmatic queries and supports standard genomic variant identifiers for lookups.","q":"What data sources and formats does gtex-database provide access to?"}],"shadow_tags":["regulatory-genomics","variant-interpretation","expression-qtl","tissue-atlas","gwas-integration","splicing-analysis","transcriptomics-database","colocalization-ready","non-coding-variants","multi-tissue-analysis"],"summary_rewrite":"Access the GTEx portal's REST API to explore how genetic variants regulate gene expression across 54 human tissues. Find eQTL associations for your GWAS variants, retrieve tissue-specific expression levels, and identify splicing QTLs to uncover regulatory mechanisms underlying non-coding variants."},"files":[{"bytes":11034,"path":"skills/12-\u79d1\u5b66\u6570\u636e\u5e93/gtex-database/SKILL.md","sha256":"aff87c4f25bb3c0783f16643a2abb28ed4d9411dfd4bd5e216ca84947102deb7","url":"https://skillfed.io/files/LeonChaoX/qinyan-academic-skills/gtex-database/f162ffee/SKILL.md"}],"id":"LeonChaoX/qinyan-academic-skills/gtex-database","links":{"html":"https://skillfed.io/LeonChaoX/qinyan-academic-skills/gtex-database","md":"https://skillfed.io/LeonChaoX/qinyan-academic-skills/gtex-database.md","repo":"https://github.com/LeonChaoX/qinyan-academic-skills"},"meta":{"agents_supported":[],"first_seen":"2026-07-28","forks":62,"language":"Python","last_updated":"2026-07-20","license":"MIT","name":"gtex-database","publisher":"LeonChaoX","stars":725},"relations":{"similar":[{"id":"google-deepmind/science-skills/gtex_database"},{"id":"mims-harvard/ToolUniverse/tooluniverse-epigenomics-chromatin"},{"id":"mims-harvard/ToolUniverse/tooluniverse-variant-to-mechanism"},{"id":"synthetic-sciences/openscience/curated-bio-datasets"},{"id":"mims-harvard/ToolUniverse/tooluniverse-regulatory-variant-analysis"},{"id":"mims-harvard/ToolUniverse/tooluniverse-pathway-disease-genetics"},{"id":"mims-harvard/ToolUniverse/tooluniverse-gene-regulatory-networks"},{"id":"mims-harvard/ToolUniverse/tooluniverse-gwas-finemapping"},{"id":"google-deepmind/science-skills/human_protein_atlas_database"},{"id":"mims-harvard/ToolUniverse/tooluniverse-regulatory-genomics"}]},"slug":{"owner":"LeonChaoX","repo":"qinyan-academic-skills","skill":"gtex-database"},"version":"f162ffee"}