{"categories":[{"label":"Information Analysis","url":"https://skillfed.io/packages/category/scientific-engineering-information-analysis/3"}],"enrichment":{"capability":"A Python C extension for reading and writing bigWig and bigBed genomic data files, with support for local and remote file access via libBigWig.","skillfed_tags":["bioinformatics","genomics","file-format"],"use_cases":["Query mean coverage or peak values across genomic regions from public datasets","Extract base-level signal data for a chromosome range to feed into downstream analysis","Create bigWig files from interval-value data for visualization in genome browsers","Compute summary statistics (min/max/std) over binned intervals for rapid region comparisons","Access remote bigBed files without downloading entire files locally"],"what_it_does":"pyBigWig is a Python wrapper around libBigWig that lets you read and write bigWig and bigBed files\u2014standard formats for storing genomic coordinate data and associated numeric values. It handles both local files and remote access over HTTP, making it useful for working with public genome browser datasets. The package is implemented as a C extension for performance, so it compiles at install time and requires system libraries.\n\nYou use it to open files, query summary statistics (mean, max, min, coverage, standard deviation) over genomic ranges, retrieve individual base values, and access interval data. For writing, you create a new file, add a header with chromosome information, and append intervals with values. The package supports exact or approximate statistics via zoom levels, and integrates with numpy for efficient array operations.","worth_installing":"Yes, if you work with bigWig or bigBed genomic data files. The package is stable, actively maintained, and has no known vulnerabilities. Install friction is moderate due to C compilation and system library requirements, but these are standard in bioinformatics environments. MIT license poses no restrictions."},"id":"pybigwig","links":{"html":"https://skillfed.io/packages/pybigwig","md":"https://skillfed.io/packages/pybigwig.md","pypi":"https://pypi.org/project/pybigwig/"},"maintenance":{"status":"active"},"meta":{"latest_release":"2026-01-14","license_spdx":null,"license_treatment":"permissive","name":"pyBigWig","python_support":"supports_current","summary":"A package for accessing bigWig files using libBigWig"},"popularity":{"monthly_downloads":164324,"position":10553,"tier":"top_15000"},"security":{"n_vulnerabilities":0},"version":"0.3.25"}